Born in Este, his family moved to Chioggia when he was just three years old. After completing his basic studies, he learned the skills of painting at the Higher Institute of Art and the Free School of Nude of the Accademia in Venice, and in a short time he became a pupil of the painter Virgilio Guidi, with whom he shared for many years his studio.
Among his works there are also large frescoes and portraits, including works that were commissioned by the family of Lords Cini. He decorated many churches, including the chapel next to the cemetery of Chioggia, where you can admire the wonderful art piece above the altar, dedicated to all those who lost their lives during the First World War. Initially, at young age, he’s considered "novcentista", later he then devotes himself to a realistic impressionism. He also worked as an illustrator for several years at the Illustrated Gazzettino directed by Talamini. His early works carry the name of art Guglielmo da Este,after the ‘70s with Guglielmo alone.